The results of the surgical management of 161 cases of ileal perforation due to typhoid fever are presented. Most were seen after an illness of two to four weeks, and because of delays in seeking hospital admission, more than half were explored more than 24 hours after their perforation occurred.
All patients were prepared for operation with nasogastric suction, intravenous fluids, and anti-biotics. At laparotomy, 4G% had considerable quantities of pus and small bowel contents in the peritoneal cavity and the remainder had localized abscesses; there were no instances of localization of the perforation. One hundred three of these patients underwent simple closure of their perforations, while 43 underwent small bowel resection, usually because of multiple perforations. Exteriorization or drainage were performed only in patients who were too sick to tolerate a more appropriate procedure. The overall mortality was 9. 9%. ´The authors believe that typhoid perforations can best be dealt with at operation. Delay in operative intervention adversely affects the survival rate after surgery Chloramphenical is used as the drug of choice.
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